Abraham Rami Tzafriri, Lucas Rotllant Daurella, John Keating, Fernando Garcia Polite, Xiaojian Li, Lynn Bailey, Peter Markham, Debashis Dutta, Hans-Peter Stoll, Elazer R. Edelman. “Tracking tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents”
Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) specifically designed for local-drug delivery. We developed immunofluorescence (IF) methods to contrast the arterial distribution of Sirolimus and Biolimus A9 after implantation of polymer-free drug-coated stents (PF DCS) in the pig coronary artery model.
Presented at the Transcatheter Cardiovascular Therapeutics (TCT) Sept 21-25, 2018, San Diego, CA.