Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). We evaluated the effects of […]
Tag Archives: PMM
Journal of Orthopaedic Research: Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system
McSweeney AL, Zani BG, Baird R, Stanley JR, Hayward A, Markham PM, Kopia GA, Edelman ER, Rabiner R. Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system Summary: Cone healing, biocompatibility, and safety employing the IlluminOss System (IS), comprised of an inflatable balloon filled with photopolymerizable liquid monomer, was evaluated […]
EuroIntervention: Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents
Kolandaivelu K, Bailey L, Buzzi S, Zucker A, Milleret V, Ziogas A, Ehrbar M, Khattab AA, Stanley JRL, Wong GK, Zani B, Markham PM, Tzafriri AR, Bhatt DL, Edelman ER. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Summary: Simple surface modifications can enhance coronary […]
Ann Biomed Eng: Vascular Response to Experimental Stent Malapposition and Under-Expansion
O’Brien CC, Lopes AC, Kolandaivelu K, Kunio M, Brown J, Kolachalama VB, Conway C, Bailey L, Markham P, Costa M, Ware J, Edelman ER. Vascular Response to Experimental Stent Malapposition and Under-Expansion. Summary: Up to 80% of all endovascular stents have malapposed struts, and while some impose catastrophic events others are inconsequential. Thirteen stents were implanted […]
J Biomed Mater Res B Appl Biomater: Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep
Zani BG, Baird R, Stanley JR, Markham PM, Wilke M, Zeiter S, Beck A, Nehrbass D, Kopia GA, Edelman ER, Rabiner R. Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep. Summary: Percutaneous intramedullary fixation may provide an ideal method for stabilization of bone fractures, while avoiding the need for large […]
EuroIntervention: Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity
Pathak A, Coleman L, Roth A, Stanley J, Bailey L, Markham P, Ewen S, Morel C, Despas F, Honton B, Senard JM, Fajadet J, Mahfoud F. Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. Summary: Catheter-based ultrasound delivered within a cooling balloon is effective […]
Sci Transl Med: Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension
Tzafriri AR, Keating JH, Markham PM, Spognardi AM, L Stanley JR, Wong G, Zani BG, Highsmith D, O’Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Summary: Renal denervation (RDN) is a treatment option for patients with hypertension resistant to conventional therapy. Clinical trials […]
EuroIntervention: Particulates from hydrophilic-coated guiding sheaths embolise to the brain
Stanley JR, Tzafriri AR, Regan K, LaRochelle A, Wong G, Zani BG, Markham PM, Bailey L, Spognardi A, Kopia GA, Edelman ER. Particulates from hydrophilic-coated guiding sheaths embolise to the brain. Summary: The hydrophilic coating on a clinically used guiding sheath readily avulses and embolises to the brain during deployment in a porcine model. Further documentation […]
Circ Cardiovasc Interv: Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation
Sakakura K, Ladich E, Fuimaono K, Grunewald D, O’Fallon P, Spognardi AM, Markham P, Otsuka F, Yahagi K, Shen K, Kolodgie FD, Joner M, Virmani R. Comparison of renal artery, soft tissue, and nerve damage after irrigated versus nonirrigated radiofrequency ablation. Summary: The long-term efficacy of radiofrequency ablation of renal autonomic nerves has been proven in […]
J Am Coll Cardiol: Innervation patterns may limit response to endovascular renal denervation
Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation. Summary: The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected […]