Abraham Rami Tzafriri PhD, Fernando Garcia-Polite PhD, John Keating DVM DACVP, Raffaele Melidone DVM DACVP, Jennifer Knutson BS, Peter Markham MS, Elazer R. Edelman MD PhD, Felix Mahfoud MD. “Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation.” FULL ARTICLE Summary: Treatment of type 2 […]
Tag Archives: PMM
Biomaterials: Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients
Abraham R. Tzafriri, Benny Muraj, Fernando Garcia-Polite, Antonio G. Salazar-Martín, Peter Markham, Brett Zani, Anna Spognardi, Mazen Albaghdadi, Steve Alston, Elazer R. Edelman. “Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients.” Summary: Paclitaxel coated balloon catheters (PCB) were developed as a polymer-free non-implantable alternative to drug […]
Press Release: CBSET’s CEO Peter Markham honored as ‘2019 Biomedical Research Business Leader’ by Massachusetts Society for Medical Research (MSMR)
LEXINGTON, MA, Oct. 24, 2019 — CBSET Inc., a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today that its co-founder, president and chief executive officer, Peter Markham, has been named ‘2019 Biomedical Research Business Leader’ by the Massachusetts Society for Medical Research (MSMR). He will be honored at a […]
Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience
Mazen Albaghdadi, Fernando Garcia-Polite, Brett Zani, John Keating, Raffaele Melidone, Anna Spognardi, Peter Markham, Abraham Tzafriri. “Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience.” Summary: This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and […]
Hypertension: Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy
Hypertension editors selected this paper for their 2019 Fall Collection of High Impact Papers. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O’Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Summary: Radiofrequency renal denervation is under investigation for treatment of hypertension with […]
Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings
Tzafriri AR, Garcia-Polite F, Li X, Keating J, Balaguer JM, Zani B, Bailey L, Markham P, Kiorpes TC, Carlyle W, Edelman ER. Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Summary: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial […]
PLoS One: Sex differences in the outcomes of stent implantation in mini-swine model
Kunio M, Wong G, Markham PM, Edelman ER. Sex differences in the outcomes of stent implantation in mini-swine model. Summary: Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related […]
Circulation: Randomized Comparison of Ridaforolimus- and Zotarolimus-Eluting Coronary Stents in Patients With Coronary Artery Disease: Primary Results From the BIONICS Trial
Kandzari DE, Smits PC, Love MP, Ben-Yehuda O, Banai S, Robinson SD, Jonas M, Kornowski R, Bagur R, Iniguez A, Danenberg H, Feldman R, Jauhar R, Chandna H, Parikh M, Perlman GY, Balcells M, Markham P, Ozan MO, Genereux P, Edelman ER, Leon MB, Stone GW. Randomized Comparison of Ridaforolimus- and Zotarolimus-Eluting Coronary Stents in Patients […]
Journal of Controlled Release: Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis
Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). We evaluated the effects of […]
Journal of Orthopaedic Research: Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system
McSweeney AL, Zani BG, Baird R, Stanley JR, Hayward A, Markham PM, Kopia GA, Edelman ER, Rabiner R. Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system Summary: Cone healing, biocompatibility, and safety employing the IlluminOss System (IS), comprised of an inflatable balloon filled with photopolymerizable liquid monomer, was evaluated […]