ICI 2019: Multiyear Tissue Retention of Paclitaxel is Driven by Lesion Complexity: Insights from Experimentally Grounded Computational Modeling

Tzafriri AR. “Multiyear Tissue Retention of Paclitaxel is Driven by Lesion Complexity: Insights from Experimentally Grounded Computational Modeling“ A recent meta-analysis of randomized controlled trials investigating paclitaxel-coated balloons and stents in femoropopliteal arteries reported increased mortality risk 2-5 years after treatment, with no causal mechanism. We developed an experimentally grounded computational model to identify scenarios […]

Press Release: CBSET’s CEO Peter Markham honored as ‘2019 Biomedical Research Business Leader’ by Massachusetts Society for Medical Research (MSMR)

LEXINGTON, MA, Oct. 24, 2019 — CBSET Inc., a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today that its co-founder, president and chief executive officer, Peter Markham, has been named ‘2019 Biomedical Research Business Leader’ by the Massachusetts Society for Medical Research (MSMR). He will be honored at a […]

ICI Meeting 2019, December 8-10, 2019, Tel Aviv, Israel

Join CBSET at the ICI Meeting 2019, December 8-10, at the David Intercontinental Convention Center, Tel Aviv, Israel. The ICI Meeting is an acclaimed forum which aims to explore, fuel, spark, and be involved in the innovations that will shape the future of cardiovascular systems and beyond. ICI’s dynamic environment has contributed to this process […]

MDG Boston: Cutting Edge Advances in Auditory Device Therapies, December 4, 2019

Join CBSET at the MDG Boston Forum: Cutting Edge Advances in Auditory Device Therapies, December 4, 2019, from 4:00 – 7:00 PM at the offices of Foley Hoag LLP, Seaport West, 155 Seaport Boulevard, Boston, MA. Both CBSET and our partner, CILcare, will be at this event. Celia Belline, Co-founder & CEO of CILcare will […]

ACT 2019, November 17-20, 2019, Phoenix, AZ

Join CBSET and CILcare at ACT 2019, the 40th Annual Meeting of the American College of Toxicology and Council, November 17–20, 2019, at the JW Marriott Desert Ridge in  Phoenix, Arizona. The 40th Annual Meeting will include a wide-ranging scientific program, a welcome reception, the popular traditional poster session reception, an awards ceremony and luncheon, distinguished […]

TCT 2019: Identifying Conditions for Very Late Tissue Retention of Paclitaxel: Insights from Mechanistic Computational Modeling

Rami Tzafriri, Sahil A. Parikh, Juan Granada, Elazer R. Edelman. “Identifying Conditions for Very Late Tissue Retention of Paclitaxel: Insights from Mechanistic Computational Modeling.” Background: A recent meta-analysis of randomized controlled trials investigating paclitaxel-coated balloons and stents in the femoral and/or popliteal arteries reported an increased risk of death 2-5 years after treatment. Yet, no […]

TCT 2019: Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation

Rami Tzafriri, Felix Mahfoud, Sahil A. Parikh, Elazer Edelman. “Quantification of Procedural and Anatomical Determinants of Multi-electrode Renal Denervation” Background: The failure of the prospective, randomized, sham-controlled SYMPLICITY HTN-3 trial to show significant difference in reduction of systolic BP (SBP) in patients with resistant hypertension 6 months after RDN compared to controls was attributed in […]

AACR Special Conference on Pancreatic Cancer: Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models

Margaret Lashof-Sullivan, Amanda L. McSweeney, David T. Ting, Michael P. Kim, Ching-Wei D. Tzeng, Laura Indolfi. “Targeted and sustained drug delivery therapy for localized pancreatic cancer: In vivo validation in porcine models“ Poster presentation at AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; September 6-9, 2019; Boston, MA. Proceedings of the […]

Biointerface 2019: Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices

Michael Naimark. “Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices” Summary: Restoration of d blood flow (TICI>2b) downstream of a proximal cerebral artery has been established as the definitive treatment for acute ischemic stroke (AIS). In recent years mechanical thrombectomy (MT) using stent retrievers has overtaken thrombolysis as the therapy of choice for AIS. […]

Biointerface 2019: Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy

Rami Tzafriri. “Quantitative preclinical insights into procedural and anatomical determinants of multi-electrode renal denervation efficacy” Summary: Radiofrequency renal denervation (RDN) is under investigation for treatment of hypertension with variable success. First generation systems used a single, monopolar radiofrequency (RF) electrode to sequentially ablate a series of angularly staggered locations along the endoluminal surface of the renal […]