Attizzani GF, Bezerra HG, Chamié D, Fujino Y, Spognardi AM, Stanley JR, Yamamoto H, Mehanna E, Wang W, Carlyle WC, McClain JB, Costa MA. Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Summary: Novel vascular scaffolds aim at equipoise between safety […]
Tzafriri AR, Bailey L, Stanley JRL, Zani BG, Markham PM, Carlyle WC, McClain JB, Edelman, ER. ‘Stents with absorbable tissue-deployable coatings can distribute drug more uniformly between struts.’ Summary: We examined whether deployment of coating from drug-eluting stents (DES) into surrounding neointima could protect a crystalline drug load from luminal washout and distribute drug more efficiently […]
Nuria Oliva, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance. Summary: We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive […]
Bailey L, Groothius A, Zucker A, Buzzi S, Mader A, Ziogas A, Milleret V, Ehrbar M, Edelman ER. ‘A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization.’ TCT-637. JACC. 2012, 60(17_S):. doi:10.1016/j.jacc.2012.08.674.
Seifert P, Regan K, Zani BG, Wong G, Stanley J. ‘Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues.’ Annual National Society for Histotechnology Symposium/Convention, Vancouver, BC Canada, 2012.
Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug. Summary: Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for […]
Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. Summary: Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. […]
Diletti R, Garcia-Garcia HM, van Geuns RJ, Farooq V, Bailey L, Rousselle S, Kopia G, Easterbrook W, Pomeranz M, Serruys P. Angiographic and Histological Results Following Implantation of a Novel Stent-On-A-Wire in the Animal Model. Summary: The Svelte Stent-On-A-Wire (SOAW) is a thin strut novel device consisting of a balloon-expandable cobalt-chromium stent premounted onto a single […]
Franano FN, Loree HM , Groothuis A, LaRochelle AW, Bailey EG, Ainsworth RD, Woodward SP, Tansley GD. ‘In Vivo Study of a Rotary Blood Pump System to Enhance Arteriovenous Fistula Eligibility.’ American Society for Artificial Internal Organs, San Francisco, CA, 2012.
Martorell J, Santoma P, Molins JJ, Garcia-Granada AA, Bea JA, Edelman ER, and Balcells M. Engineered arterial models to correlate blood flow to tissue biological response. Summary: This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow […]