Le KN, Hwang CW, Tzafriri A, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Summary: The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized that angiogenic therapies powerfully self-regulate by dynamically altering […]
Wu, P.I., S. Minisini, and E.R. Edelman. Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake. Summary: Dynamic architecture and motion in mechanically active target tissues can influence the pharmacokinetics of locally delivered agents. Drug transport in skeletal muscle under controlled mechanical loads was investigated. Static (0-20%) and cyclic (+/-2.5% amplitude, 0-20% mean, […]
Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose response for local arterial and tumor drug delivery. Summary: Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus […]
Burke SK, Mendenhall HV, LaRochelle A, Franano FN. ‘Recombinant Human Pancreatic Elastase (PRT-201) Dilates the Arteriovenous Graft (AVG) Outflow Vein and Increases Graft Blood Flow in a Porcine Femoral AVG Model.’ Poster and Podium presentation at: Vascular Access Society 6th International Congress; 2009 April 20-22; Rome, Italy. Summary: AVG surgery is often initially successful but ultimately […]
Tzafriri AR, Edelman ER. ‘Saturable Drug Binding Explains the Dose and Tissue Dependence of Stent Delivery.’ FDA/NHLBI/NSF Workshop on Computer Methods for Cardiovascular Devices, Bethesda, MD, 2009.
Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Summary: Heparan sulfate proteoglycans (HSPGs) are potent regulators of vascular remodeling and repair. Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells. Here […]
Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. Summary: Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now emerging. We employed computational fluid dynamic modeling tools to investigate the influence of […]
Balakrishnan B, Dooley J, Kopia G, Edelman ER. Thrombus causes fluctuations in arterial drug delivery from intravascular stents. Summary: Arterial drug concentrations determine local toxicity. As such the emergent safety concerns surrounding drug-eluting stents mandate an investigation of the factors contributing to fluctuations in arterial drug uptake. Drug-eluting stents were implanted into porcine coronary arteries,arterial drug […]
Burke SK, FNF, LaRochelle Alan, Mendenhall HV. ‘Local Application of Recombinant Human Type I Pancreatic Elastase (PRT-201) to an Arteriovenous Fistula (AVF) Increases AVF Blood Flow in a Rabbit Model.’ American Society of Nephrology, Philadelphia, PA, 2008.
Mi, L.Y., D.S. Ettenson, and E.R. Edelman. Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Summary: Intercellular communication in non-excitable cells is restricted to a limited range close to the signal source. Here, we have examined whether modification of the intracellular microenvironment could prolong the spatial proposition of […]