PERIPHERAL ARTERY DISEASE (PAD) – EXPERIMENTAL AND COMPUTATIONAL MODELING

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Join CBSET at the PCR e-Course 2020, a new digital initiative for the interventional cardiovascular community, consisting of 3 days of interactive education & innovation in interventional cardiovascular medicine, where a number of presentations will be concentrating on the latest research in peripheral artery disease (PAD).

The upcoming innovative e-Course will be spreading the latest scientific news and best practices all across the globe, on a fully complimentary basis.

CBSET is committed to the development of novel experimental and computational models for defining the barrier effects of tissue components on drugs of interest and evaluating novel endovascular therapies. CBSET's scientists have published a range of data and analyses on PAD treatments and related therapies.

Contact us to schedule an e-meeting with the researchers and authors behind some of the most advanced preclinical models for PAD in the field.





Recent scientific papers/presentations related to novel PAD therapies:

RamiCRT2019Innovation3WATCH: At CRT19, CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, was interviewed by Michael Mooney, MD, of Minneapolis Heart Institute, Abbott Northwestern hospital about CBSET’s PAD preclinical study: Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System. In this interview, Rami discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.

Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model. Abraham R.Tzafriri, AnnaMaria Spognardi, Lynn Bailey, John Keating, Peter Markham, Gary Binyamin, Maria Pizarro, Eitan Konstantino, Elazer R. Edelman. Presented at: CRT 2020, Feb 22-25; National Harbor, MD. JACC: Cardiovascular Interventions Volume 13, Issue 4, Supplement, 24 February 2020, Pages S31-S32.

stentanimationComputational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality. Abraham R.Tzafriri, Farhad Rikhtegar Nezami, Elazer R.Edelman.  Poster presentation at: CRT 2020, Feb 22-25; National Harbor, MD. JACC: Cardiovascular Interventions, Volume 13, Issue 4, Supplement, 24 February 2020, Pages S43-S44.

Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics. Abraham R.Tzafriri, Sahil A.Parikh, Elazer R.Edelman. Journal of Controlled Release. Volume 310, 28 September 2019, Pages 94-102.

Enhanced Plaque Modification of Cadaveric Human Calcified Peripheral Arteries Treated with a Vessel Preparation System. Video interview at CRT19. CBSET’s Director of Research and Innovation, Rami Tzafriri, PhD, discusses CBSET’s human cadaver model assessment of a vessel preparation system and the attributes of this particular technology that suggest it might be conducive to enhancing drug absorption.

Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman,  Journal of Controlled Release, Volume 264, 28 October 2017, Pages 203-210.

charingcrosscoatedballoonsEvaluation of a novel paclitaxel coated intravascular balloon. Abraham R. Tzafriri, PhD. Presented at CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.

Mechanisms Underlying Drug Delivery to Peripheral Arteries. Li J, Tzafriri R, Patel SM, Parikh SA. Interventional Cardiology Clinics. 2017 Apr;6(2):197-216. doi: 10.1016/j.iccl.2016.12.004.

Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model. Shammas NW, Aasen N, Bailey L, Budrewicz J, Farago T, Jarvis G. Journal of Endovascular Therapy. 2015 Aug;22(4):518-24.

Effects of Orbital Atherectomy Treatment on Drug Absorption in Calcified Peripheral Arteries. Elazer R. Edelman, MD. Presented at CRT15 – Cardiovascular Research Technologies (CRT); 2015 Feb 21-24; Washington, DC.

Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy. Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Circulation. 2013;127:2047-2055.

Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Journal of Histotechnology, 2013 March; 36 (1): 25-29.

Related CBSET Brochures:

CBSET GLP Preclinical Services

Cardiovascular Research

GLP Histopathology and Morphometry

Computational Modeling of Local Drug Delivery

Scanning Electron Microscopy