Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation.
Summary: The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected treatment efficacy.
Threshold to Biomarker Effect Renal norepinephrine levels exhibit a threshold dependence on the percentage of affected nerves (red circles), namely those residing within or at the periphery of the ablation zone (black line). Far from the ablation zones, nerves (blue circles) and ganglia (green circles) are unaffected.