FOCUS ON THROMBECTOMY & THROMBOLYSIS
CBSET's approach to the study of Thrombectomy & Thrombolysis technologies
Spurred by the high medical burden posed by neovascular stroke as well as peripheral clots and embolisms, new thrombectomy and thrombolysis technologies are continuously being developed and tested every year. While some aspects of these technologies can be tested using benchtop vascular models, the absence of good animal models has hampered further innovation and safety testing.
CBSET is committed to the development of novel experimental animal models for testing the efficacy and safety of clot retrieval, aspiration and lysis devices, leveraging methods for creating clots with consistent morphology for enabling controlled delivery and adherence, as well as facilitating comparative analysis of technologies using angiographic and histologic assessments.
Recent scientific papers/presentations related to Mechanical Thrombectomy research:
Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot mode. Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. Journal of Neuerointerventional Surgery, 2020 Oct;12(10):1008-1013. doi: 10.1136/neurintsurg-2019-015548.
Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices. M Naimark. Presented at: Biointerface 2019, Park City, Utah, September 4-6, 2019.
Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model. L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. Poster presented at: Society of Neurointerventional Surgery (SNIS), Boston, USA, July 25-29, 2016.
Rami Tzafriri, L. J. (Jack) Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Knapp, Elazer R. Edelman. Poster presented at EuroPCR, May 16-19, 2023, Paris, France.