Ischemic stroke represents the fifth most common cause of death in the western world and the number one cause of long-term disability. Systemic intravenous fibrinolysis, the prevailing gold standard in stroke therapy, is limited by strict timing parameters and modes efficacy in large strokes caused by clots in the proximal cerebral vasculature. Since 2015 multiple randomized controlled trials have demonstrated the safety and efficacy of mechanical thrombectomy with stent-retrievers in improving outcomes and reducing mortality for patients who present within 6 hours from onset of symptoms.
The field, however, is in its infancy, with new devices being developed and tested every year.
CBSET is committed to the development of novel experimental animal models for testing the efficacy and safety of clot retrieval devices, leveraging methods for creating clots with consistent morphology enabling controlled delivery and adherence and facilitating comparative analysis of thrombectomy devices using angiographic and histologic assessments.
Recent scientific papers/presentations related to Mechanical Thrombectomy research:
Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot mode. Sanchez S, Bailey L, Ducore R, Andersson T, Nogueira R, Cognard C, Ribo M, Villanova H, Rios A, Galve I. Journal of Neuerointerventional Surgery, 2020 Oct;12(10):1008-1013. doi: 10.1136/neurintsurg-2019-015548.
Swine Clot Model for the Evaluation of Mechanical Thrombectomy Devices. M Naimark. Presented at: Biointerface 2019, Park City, Utah, September 4-6, 2019.
Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model. L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. Poster presented at: Society of Neurointerventional Surgery (SNIS), Boston, USA, July 25-29, 2016.