EuroPCR 2023: Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism

Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism.  Ultrasound-assisted catheter-directed thrombolysis enhances right ventricular recovery after acute PE, but optimization is limited by lack of good animal models. We developed a porcine model […]

SOT: A Novel 3D Imaging Pipeline for Analyzing Radiofrequency Catheter Ablation in Preclinical Animal Models

A Novel 3D Imaging Pipeline for Analyzing Radiofrequency Catheter Ablation in Preclinical Animal Models. Authors: Gianna Ferron(1), Neil Patel(1), Anthony Knesis(1), Yookyung Jung(1), Stefan Linehan(1), Tim Ragan(1), Jay Budrewicz(2), David Parrillo(2), Rami Tzafriri(2) Affiliations: (1) TissueVision, Inc., Newton, MA; (2) CBSET, Inc., Lexington, MA Abstract: Radiofrequency catheter ablation uses programmed electrical stimulation to alter or […]

ICI 2022: Image Guided Renal Denervation – The Time Is Now

This presentation by Rami Tzafriri, CBSET’s Director of Research and Innovation reviewed: The scientific data underlying the procedural dependence of radiofrequency (RF) denervation therapies, including a strong dependence of thermal distribution on the locations of the treating electrodes relative to nerves, veins and lymph nodes. Computational modeling results comparing the thermal patterns achieved by RF […]

CRT Online 2021: Atraumatic Endoluminal Microincisions Enhance Balloon-based Drug Delivery In Complex Porcine Restenotic Lesions

Abraham R. Tzafriri, David Marlevi, Jay Budrewicz, Lynn Bailey, Peter Markham, Mazen Albaghdadi, Farhad Rikhtegar Nezami and Elazer R. Edelman. ‘Atraumatic Endoluminal Microincisions Enhance Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions.’ Presented at: CRT Online 2021. Background: We examined whether endoluminal microincisions could enhance arterial drug uptake and retention after paclitaxel-coated balloon (PCB) treatments of […]

ARO 2021: Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice

Misty J. Williams-Fritze, Benny Muraj, Amanda McSweeney, Fernando Garcia-Polite, Raffaele Melidone, Jonathon Kirk, Rami Tzafriri , Cyrille Sage. Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice. Background: Cochlear implants (CI) are a growing market currently valued at $1.67 billion and projected to grow 10.6%/year from 2020 to 2027 (Figure 1). Since the first […]

LINC 2021: Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions

Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham, Maxen Albaghdadi, Elazer Edelman. Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Live presentation abstract: This study examined if and how a vessel preparation system delivering micro-incisions could enhance in vivo paclitaxel (delivered from a DCB) retention in […]

TCT Connect 2020: 371-Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution

Abraham Tzafriri , Benny Muraj , Fernando Gacia-Polite , Antonio-Gabino Salazar-Martin , Peter Markham , Anna-Maria Spognardi , Brett Zani , Mazen Albaghdadi , Steve Alston , and Elazer Edelman. “Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution.” Background: Paclitaxel-coated balloons (PCBs) control iliofemoral atherosclerotic lesions, yet restenosis rates remain hight without calss effect. We […]

Digestive Diseases Week: A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures

Kevin Wood, Jay Budrewicz, Moises Rivera Bermudez, Katrina Hansen. “A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures.” Summary: There are a host of disease pathologies within the biliary anatomy that manifest in luminal obstruction and consequential dilation. An Endoscopic Retrograde Cholangiopancreotography (ERCP)-guided biliary drainage procedure is used as the primary approach to […]

CRT 2020: Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality

Abraham R.Tzafriri, Farhad Rikhtegar Nezami, Elazer R.Edelman. ‘Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality.’ Poster presentation at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: Computational modeling is revolutionizing device design and evaluation. While great progress has been made in virtual stent angioplasty and computational hemodynamics, drug-delivery modeling in patient-specific geometries remains […]