Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism. Ultrasound-assisted catheter-directed thrombolysis enhances right ventricular recovery after acute PE, but optimization is limited by lack of good animal models. We developed a porcine model […]
ISID1564 – Analyzing the effect of radiofrequency catheter ablation on tissue using a novel 3D imaging pipeline. Radiofrequency catheter ablation uses programmed electrical stimulation to alter or destroy cells causing irregular parenchymal activity. Despite its history of clinical adoption across a range of therapeutic areas, the 3D volume of ablated tissue has yet to be […]
A Novel 3D Imaging Pipeline for Analyzing Radiofrequency Catheter Ablation in Preclinical Animal Models. Authors: Gianna Ferron(1), Neil Patel(1), Anthony Knesis(1), Yookyung Jung(1), Stefan Linehan(1), Tim Ragan(1), Jay Budrewicz(2), David Parrillo(2), Rami Tzafriri(2) Affiliations: (1) TissueVision, Inc., Newton, MA; (2) CBSET, Inc., Lexington, MA Abstract: Radiofrequency catheter ablation uses programmed electrical stimulation to alter or […]
This presentation by Rami Tzafriri, CBSET’s Director of Research and Innovation reviewed: The scientific data underlying the procedural dependence of radiofrequency (RF) denervation therapies, including a strong dependence of thermal distribution on the locations of the treating electrodes relative to nerves, veins and lymph nodes. Computational modeling results comparing the thermal patterns achieved by RF […]
Abraham R. Tzafriri, David Marlevi, Jay Budrewicz, Lynn Bailey, Peter Markham, Mazen Albaghdadi, Farhad Rikhtegar Nezami and Elazer R. Edelman. ‘Atraumatic Endoluminal Microincisions Enhance Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions.’ Presented at: CRT Online 2021. Background: We examined whether endoluminal microincisions could enhance arterial drug uptake and retention after paclitaxel-coated balloon (PCB) treatments of […]
Misty J. Williams-Fritze, Benny Muraj, Amanda McSweeney, Fernando Garcia-Polite, Raffaele Melidone, Jonathon Kirk, Rami Tzafriri , Cyrille Sage. Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice. Background: Cochlear implants (CI) are a growing market currently valued at $1.67 billion and projected to grow 10.6%/year from 2020 to 2027 (Figure 1). Since the first […]
Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham, Maxen Albaghdadi, Elazer Edelman. Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Live presentation abstract: This study examined if and how a vessel preparation system delivering micro-incisions could enhance in vivo paclitaxel (delivered from a DCB) retention in […]
Abraham Tzafriri , Benny Muraj , Fernando Gacia-Polite , Antonio-Gabino Salazar-Martin , Peter Markham , Anna-Maria Spognardi , Brett Zani , Mazen Albaghdadi , Steve Alston , and Elazer Edelman. “Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution.” Background: Paclitaxel-coated balloons (PCBs) control iliofemoral atherosclerotic lesions, yet restenosis rates remain hight without calss effect. We […]
Kevin Wood, Jay Budrewicz, Moises Rivera Bermudez, Katrina Hansen. “A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures.” Summary: There are a host of disease pathologies within the biliary anatomy that manifest in luminal obstruction and consequential dilation. An Endoscopic Retrograde Cholangiopancreotography (ERCP)-guided biliary drainage procedure is used as the primary approach to […]
Abraham R.Tzafriri, Farhad Rikhtegar Nezami, Elazer R.Edelman. ‘Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality.’ Poster presentation at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: Computational modeling is revolutionizing device design and evaluation. While great progress has been made in virtual stent angioplasty and computational hemodynamics, drug-delivery modeling in patient-specific geometries remains […]