CRT Online 2021: Atraumatic Endoluminal Microincisions Enhance Balloon-based Drug Delivery In Complex Porcine Restenotic Lesions

Abraham R. Tzafriri, David Marlevi, Jay Budrewicz, Lynn Bailey, Peter Markham, Mazen Albaghdadi, Farhad Rikhtegar Nezami and Elazer R. Edelman. ‘Atraumatic Endoluminal Microincisions Enhance Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions.’ Presented at: CRT Online 2021. Background: We examined whether endoluminal microincisions could enhance arterial drug uptake and retention after paclitaxel-coated balloon (PCB) treatments of […]

ARO 2021: Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice

Misty J. Williams-Fritze, Benny Muraj, Amanda McSweeney, Fernando Garcia-Polite, Raffaele Melidone, Jonathon Kirk, Rami Tzafriri , Cyrille Sage. Cochlear Implant: Mini Swine or Sheep? Such a Tricky Choice. Background: Cochlear implants (CI) are a growing market currently valued at $1.67 billion and projected to grow 10.6%/year from 2020 to 2027 (Figure 1). Since the first […]

LINC 2021: Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions

Rami Tzafriri, Jay Budrewicz, Lynn Bailey, Peter Markham, Maxen Albaghdadi, Elazer Edelman. Lesion Modification with a Micro-Incision Vessel Preparation System Enhances Balloon-Based Drug Delivery in Complex Porcine Restenotic Lesions. Live presentation abstract: This study examined if and how a vessel preparation system delivering micro-incisions could enhance in vivo paclitaxel (delivered from a DCB) retention in […]

TCT Connect 2020: 371-Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution

Abraham Tzafriri , Benny Muraj , Fernando Gacia-Polite , Antonio-Gabino Salazar-Martin , Peter Markham , Anna-Maria Spognardi , Brett Zani , Mazen Albaghdadi , Steve Alston , and Elazer Edelman. “Drug-Coated Balloon Contact Pressure Predicts Endoluminal Coating Distribution.” Background: Paclitaxel-coated balloons (PCBs) control iliofemoral atherosclerotic lesions, yet restenosis rates remain hight without calss effect. We […]

Digestive Diseases Week: A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures

Kevin Wood, Jay Budrewicz, Moises Rivera Bermudez, Katrina Hansen. “A novel modified jejunum model for endoscopic ultrasonography-guided biliary drainage procedures.” Summary: There are a host of disease pathologies within the biliary anatomy that manifest in luminal obstruction and consequential dilation. An Endoscopic Retrograde Cholangiopancreotography (ERCP)-guided biliary drainage procedure is used as the primary approach to […]

CRT 2020: Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality

Abraham R.Tzafriri, Farhad Rikhtegar Nezami, Elazer R.Edelman. ‘Computational Prediction Of Drug-eluting Stent Performance In Patient-specific Arteries – A Virtual Reality.’ Poster presentation at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: Computational modeling is revolutionizing device design and evaluation. While great progress has been made in virtual stent angioplasty and computational hemodynamics, drug-delivery modeling in patient-specific geometries remains […]

CRT 2020: Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model

Abraham R.Tzafriri, AnnaMariaSpognardi, LynnBailey, JohnKeating, PeterMarkham, GaryBinyamin, MariaPizarro, EitanKonstantino, Elazer R.Edelman. ‘Six Month Safety Evaluation Of The Chocolate Touch™ Drug-coated Balloon Catheter In The Swine Peripheral Artery Model.’ Presented at: CRT 2020, Feb 22-25; National Harbor, MD. Summary: We evaluated the preclinical safety of a novel paclitaxel-coated balloon catheter (PCB) with a nitinol constraining structure positioned over it, […]

CRT 2020: Procedural and Anatomical Determinants of Multi-Electrode Renal Denervation: Preclinical Versus Clinical

Abraham R.Tzafriri. ‘Procedural and Anatomical Determinants of Multi-Electrode Renal Denervation: Preclinical Versus Clinical.’  Summary: The failure of the prospective, randomized, sham-controlled SYMPLICITY HTN-3 trial to show significant difference in reduction of systolic BP (SBP) in patients with resistant hypertension 6 months after RDN compared to controls was attributed in part to procedural limitations in first generation […]

9th Bio-Fluid Symposium: Transient subject-specific drug delivery in stented arteries: physics-based simulation of controlled release and retention

Farhad Rikhtegar Nezami, Abraham R. Tzafriri, Elazer R.Edelman. ‘Transient subject-specific drug delivery in stented arteries: physics-based simulation of controlled release and retention.’  Summary: Drug-eluting stents are the mainstay therapy for obstructive arterial disease, yet further innovation is hampered by cost and lack of experimental techniques. In silico models, akin to what developed here, offer flexible and […]

ARO 2020: Large Animal Models for Auditory Research: Guide to the Perplexed

Suchi Raghunathan, Randolph Abutin, Amanda McSweeney, Misty J. Williams-Fritze, Rami Tzafriri, Cyrille Sage. ‘Large Animal Models for Auditory Research: Guide to the Perplexed.’ Poster presentation at: ARO Midwinter Meeting, Jan 25-29, 2020, San Jose, CA. Summary: Auditory studies, including those evaluating ototoxicity and pharmacokinetics (PK), are typically performed using rodent models. Some studies, however, may require a […]