CELEBRATING 12 YEARS AT CBSET... Dr. Brett Zani joined the CBSET team in 2010. His biomedical research background ranges from molecular cardiology and cancer biology to cardiovascular physiology and tissue regeneration. He holds an MS and PhD in Cellular and Integrative Physiology from Indiana University School of Medicine.
TWO THINGS YOU SHOULD KNOW ABOUT DR. BRETT ZANI
1: He is a well-rounded scientific authority.
Brett has co-authored 58 abstracts and peer-reviewed articles on topics ranging from splenic artery denervation to intercellular communication and cell migration, and he is a co-inventor on two patents and two pending patents. He leads the study director group at CBSET, where he is intimately involved in the evaluation of new medical therapies.
“My roles include directing studies and supporting our study director team. Collectively, we are involved in projects supporting research and development of medical devices, cell-based therapies, and pharmaceuticals,” he says. “As a not-for-profit preclinical/translational research institute, CBSET is dedicated to providing a collaborative/multidisciplinary approach through unbiased scientific advice, extensive regulatory expertise, and a drive to understand how mechanisms of action can be applied to support product differentiation, all of which, when combined, creates an innovative and iterative approach to accelerating clinical development.”
2: He is a scientist's scientist.
As a postdoctoral associate at the Harvard-MIT Division of Health Sciences and Technology prior to joining CBSET, Brett worked in the laboratory of Dr. Elazer Edelman, Director of Medical Engineering and Science at MIT. Brett investigated the ability of tissue-engineered cell implants to repair airway injury, discovering tissue-engineered endothelial and epithelial cells differentially and synergistically mediate airway repair. In addition, he investigated the biology of epithelial cell interactions with other cell types and discovered novel mechanisms of epithelial cell migration and intercellular signaling, which earned him a ‘Koch Institute Image Award’ (2012) for his image (below): "Crossing Over: Cells Move Through an Epithelial Bridge” (https://ki-galleries.mit.edu/2012/zani). His scientific publications have appeared in peer-reviewed journals including Proceedings of the National Academy of Sciences, Science Translational Medicine, Biomaterials, Translational Research, and the Journal of Controlled Release, among many others.
News and Publications
Biomaterials: Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients
Athrosc Sports Med Rehabil: Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee
Lymphat Res Biol: Development of a Porcine Lymph Drainage Model to Study Particle Migration
Translational Research: Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience
Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings
Journal of Controlled Release: Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis
Journal of Orthopaedic Research: Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system
EuroIntervention: Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents
J Biomed Mater Res B Appl Biomater: Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep
Sci Transl Med: Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension
EuroIntervention: Particulates from hydrophilic-coated guiding sheaths embolise to the brain
J Hypertens: Evaluation of renal nerve morphological changes and norepinephrine levels following treatment with novel bipolar radiofrequency delivery systems in a porcine model.
Journal of Histotechnology: Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues.
Journal of Invasive Cardiology: Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.
Journal of Controlled Release: Enhanced Drug Delivery Capabilities from Stents Coated with Absorbable Polymer and Crystalline Drug
Proc Natl Acad Sci U S A: Tissue engineered endothelial and epithelial implants differentially and synergistically regulate airway repair