CBSET now offers real-time live streaming of procedures to support collaboration and participation.

Live streaming brings our OR to you.

CBSET's fully-equipped surgical suites include broadcasting of procedures through a secure Internet connection.

Learn more about CBSET's state-of-the art facilities and equipment. 

Auditory Efficacy and Safety Services from CBSET & CILcare

CBSET and a premier CRO specializing in hearing, CILcare, have created a strategic alliance to offer a broad range of cutting-edge preclinical services for the assessment of drugs, medical devices, and gene and cell-based therapies for auditory functions in a GLP-compliant environment.

Extensive History in Otology Research

Based on an extensive history in basic and clinical otology research, we provide a broad range of in vivo models, enabling studies from proof-of-concept and non-GLP programs through fully GLP-compliant safety assessments. Inner ear and systemic pharmacokinetics, ototoxicity, and safety and efficacy studies may be conducted in a variety of preclinical species and models including device-mediated therapy (such as cochlear implants and implantable drug delivery systems), biologics and therapeutic proteins, small molecules, cell products, or gene therapy vectors, all in accordance with best practices and applicable regulatory guidelines.

A Broad Range of Technical Capabilities for Auditory Therapy Assessment

Our technical capabilities include in-life assessment with high-throughput electrophysiological measurements and post-mortem assessments via immunohistochemistry, histopathology, and hair cell and ribbon synapse quantification. In addition, our otic research scientists and surgeons can provide method development support to adapt or replicate challenging technical procedures including cochleostomy, canalostomy, and round window injections targeting different sites of interest.

  • Expertise in auditory assessment
    • ABR (Auditory Brainstem Response) measurements
    • Otoscopic evaluation
    • Tympanometry
    • Cytocochleogram
    • Ribbon synapses counting
    • Histopathology and immunohistochemistry
    • Imaging
    • Cochlear explants
  • Animal models
    • Drug-induced ototoxicity
    • Otitis media
  • Animal species
    • Rodents
    • Guinea pigs
    • Chinchilla
    • Swine
    • Sheep
  • Routes of delivery
    • Transtympanic
    • Round window
    • Intracochlear
    • Intrabullar
  • Samplings
    • Perilymph & cochlea
    • Tympanic bulla
    • CSF and other tissues


ABR are electric potentials recorded from scalp electrodes. This non-invasive method allows determination of auditory response thresholds. It is translational between rodents and humans, and is commonly used for screening newborns.


The cytocochlelogram allows histopathological assessment of ototoxic damage on inner hair cell and outer hair cell of the cochlea, with anatomical localization corresponding to predicable patterns of functional deficits.

Watch: HEARING MATTERS - What Can You Do To Prevent Ototoxicity?

Watch: A focus on new treatments for hearing loss.