Burke SK, Mendenhall HV, LaRochelle A, Franano FN. ‘Recombinant Human Pancreatic Elastase (PRT-201) Dilates the Arteriovenous Graft (AVG) Outflow Vein and Increases Graft Blood Flow in a Porcine Femoral AVG Model.’
Poster and Podium presentation at: Vascular Access Society 6th International Congress; 2009 April 20-22; Rome, Italy.
Summary: AVG surgery is often initially successful but ultimately fails, usually due to neointima formation, stenosis, and thrombosis. PRT- 201 removes elastin fibers from blood vessels causing a change in vessel compliance and dilation. The aim of this study was to determine the effect of PRT-201 treatment on AVG outflow vein diameter and blood flow, AVG patency, and safety in pigs.