Abraham R. Tzafriri, PhD, Fernando Garcia-Polite, PhD, John H. Keating DVM, DACVP, Anna-Maria Spognardi, BS, Peter Markham, MS, Elazer Edelman, MD, PhD. “Superior and proximal nerves in porcine renal arteries are least accessible to radiofrequency ablation due to shielding by peri-arterial blood vessels and lymph nodes.”
Summary: Periarterial lymph nodes and blood vessels can shield nerves from radiofrequency heating and limit the efficacy of catheter based renal denervation (RDN). We quantified the distributions of accessible and shielded nerves surrounding porcine renal arteries and found significant dependencies on nerve distance from lumen, location along the length of the renal artery and circumferential quadrant.
Presented at the Transcatheter Cardiovascular Therapeutics (TCT) Sept 21-25, 2018, San Diego, CA.