Tzafriri AR; Markham PM; Goshgarian J; Schulz-Jander D; Tunev S; Melder RJ; Stone GW; Edelman ER.‘Titratable drug delivery from drug filled stents.’
Poster presented at: Transcatheter Cardiovascular Therapeutics (TCT); Oct 11-14; San Francisco, CA.
Summary: Polymer-free controlled drug elution has proved challenging for surface-modified drug eluting stents. Drug-filled stents (DFS; Medtronic, Santa Rosa CA) however, are a novel platform for polymer-free drug delivery in which the drug is contained in a hollow stent and released through laser drilled holes along the abluminal surface of the stent. We hypothesized that hole-size can modulate in vivo drug release kinetics from DFS.