Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Mueller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, and Jeffrey H. Stern. The Developmental Stage of Adult Human Stem […]
– “This partnership brings together CBSETs preclinical surgery, drug delivery, and histopathology expertise with CILcare’s proprietary functional tests for assessing alterations to the auditory system in GLP-compliant state-of-the-art facilities. Our new services will enable companies to accelerate their development of novel therapies for hearing loss and be instrumental in supporting their regulatory submissions.” – Peter […]
Company to launch new service at next week’s “ISSCR 2017 Annual Meeting” “CBSET is the ideal partner in preparing, presenting, and defending GLP studies for regulatory review.”—Michael Naimark, CBSET LEXINGTON, Mass., June 8, 2017 — CBSET Inc., a non-profit GLP translational research institute that specializes in the advancement of novel therapies, announced today that it has […]
Abraham Rami Tzafriri, Lynn Bailey, John Keating, Peter Markham, Debashis Dutta, Margaret Kayo, Elazer R. Edelman. ‘Sirolimus analog lipophilicity dictates release kinetics and tissue retention after implantation of polymer free drug coated stents.’ Poster presented at: EuroPCR, May 16-19, 2017, Paris, France.
Peripheral Innovation: Evaluation of a novel paclitaxel coated intravascular balloon. Rami Tzafriri, PhD Summary: The presentation illustrated an innovative preclinical paradigm for evaluating and optimizing novel drug-coated balloon technologies by combining bioanalysis with imaging of the coating distribution. Presented at: CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.
Kolandaivelu K, Bailey L, Buzzi S, Zucker A, Milleret V, Ziogas A, Ehrbar M, Khattab AA, Stanley JRL, Wong GK, Zani B, Markham PM, Tzafriri AR, Bhatt DL, Edelman ER. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Summary: Simple surface modifications can enhance coronary […]
*BTI* From Benchtop to Clinical Trial: Examples of technology development. Rami Tzafriri, PhD Summary: Drawing on examples from renal denervation and other thought-leader debates at the conference, the presentation focused on several issues, including whether benchtop-to-clinical is the only path for new medical technologies, the roles and advantages of preclinical vs clinical trials in technology development, and […]
Li J, Tzafriri R, Patel SM, Parikh SA. Mechanisms Underlying Drug Delivery to Peripheral Arteries. Summary: Delivery of drugs onto arterial targets via endovascular devices commands several principles: dissolution, diffusion, convection, drug binding, barriers to absorption, and interaction between the drug, delivery vehicle, and accepting arterial wall. The understanding of drug delivery in the coronary […]
Georgia S. Karanasiou, Michail I. Papafaklis, Claire Conway, Lampros K. Michalis, Rami Tzafriri, Elazer R. Edelman, Dimitrios I. Fotiadis. Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling Summary: Coronary stents have revolutionized the treatment of coronary artery disease. Improvement in clinical outcomes requires detailed evaluation of the performance of stent biomechanics and the effectiveness as well […]
CBSET, IlluminOss Medical Data Published in Journal of Orthopaedic Research IlluminOss* System provides minimally invasive approach designed to replace splints, casts, metal fixator plates and rods to stabilize broken bones LEXINGTON, Mass., March 23, 2017 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today it […]