Respirology: Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter

Tsukada H, Entcheva-Dimitrov P, Ernst A, Rafeq S, Keating JH, Seward KP, Yarmus L. Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter. Summary: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity of treatment […]

Tufts CTSI TranslationalDay2017: Lessons learned from the front lines

Rami Tzafriri, PhD and Michael Naimark, MS. “Lessons Learned from the Front Lines.” Summary: The Directors of Research and Innovation and Business Development presented advice and lessons learned from CBSET Inc.’s experiences on how to differentiate a new technology and navigate through a successful path to the market, and how to find the correct testing paradigm […]

Press Release: CILcare, CBSET, and Draper partner to accelerate hearing loss treatment and care

CAMBRIDGE, Mass., Nov. 6, 2017 – CILcare Inc., the world’s leading clinical research organization specializing in ear disorders, and CBSET Inc., a non-profit translational research institute specializing in the advancement of novel therapies, announced today the initiation of a collaboration with Draper, a not-for-profit technology development company focused on the design, development and deployment of […]

TCT 2017: Stent based tissue drug and binding target protein distributions: durable versus deployable coatings

Rami Tzafriri, PhD. “Stent based tissue drug and binding target protein distributions: durable versus deployable coatings.” Summary: We developed immunofluorescence (IF) methods to track drug and target protein distribution in stented arteries, to aid the development and assessment of novel stent designs. Xience Pro (74 μg Everolimus/3.0×15 mm, durable coating) and MiStent (135 μg Sirolimus/3.0×15 mm, […]

Press Release: CBSET Chairman Elazer Edelman, MD, PhD, has received the “TCT 2017 Career Achievement Award”

LEXINGTON, Mass., November 1, 2017  — CBSET Inc., a non-profit translational research institute that specializes in the advancement of novel therapies, announced today that Internationally renowned cardiologist, Elazer Edelman, MD, PhD, has received the “TCT Career Achievement Award” at TCT 2017 in Denver, Colorado. TCT Directors, Martin B. Leon, MD, and Gregg W. Stone, MD, […]

World Pharma Today: Auditory Therapy, Ototoxicity, and GLP Compliance: Will the promising market for ear disorder treatments follow ophthalmology’s dramatic growth curve?

by Michael Naimark, Director of Business Development, CBSET, Inc. and Marie-Pierre Pasdelou, PharmD, founder and the Chief Development Officer, CILcare Hearing research and development aims to prevent hearing loss, halt its progression, or reverse deficits through a range of approaches. Unfortunately progress to date has been limited and the FDA has yet to recognize any […]

SIB 2017: Particulate embolization from catheter coatings

Rami Tzafriri, PhD. ‘Particulate embolization from catheter coatings.’ Summary: Medical catheters permit minimally invasive external access for monitoring, imaging, sampling, local delivery of therapeutic agents, and placement of devices like endovascular stents, aneurysm coils and transcatheter valves. Catheter coatings are employed extensively as enhancers of device lubriciousness/ steerability and as platforms for local drug delivery. […]

Journal of Controlled Release: Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis

Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). We evaluated the effects of […]

VIVA2017: Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention

Rami Tzafriri, PhD. “Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention.” Summary: Drug coated balloons are a promising therapy for peripheral arterial disease, but differences in efficacy between devices and non-responders cannot be understood using current methods. To address this void, we developed methods for visualizing and quantifying coating distribution on arterial surfaces […]

Press Release: Lesion Preparation Using Diamondback 360® Orbital Atherectomy System Enhances Paclitaxel Distribution in Calcified Peripheral Arteries: CBSET Data Published in Journal of Controlled Release

“This preclinical demonstration of the hindrance of drug distribution by calcified tissue and improved drug delivery after modification of calcified atherosclerotic plaque could have significant clinical implications.” – Michael R. Jaff*, D.O. President, Newton-Wellesley Hospital; Professor of Medicine, Harvard Medical School LEXINGTON, Mass., September 11, 2017  — CBSET Inc., a not-for-profit preclinical research institute dedicated to […]