Stem Cell Reports: The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue

Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Mueller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, and Jeffrey H. Stern. The Developmental Stage of Adult Human Stem […]

Press Release: CBSET and CILcare partner to offer cutting-edge preclinical research services for the evaluation of hearing disorders and regenerative therapies

– “This partnership brings together CBSETs preclinical surgery, drug delivery, and histopathology expertise with CILcare’s proprietary functional tests for assessing alterations to the auditory system in GLP-compliant state-of-the-art facilities. Our new services will enable companies to accelerate their development of novel therapies for hearing loss and be instrumental in supporting their regulatory submissions.” – Peter […]

Press Release: CBSET expands its preclinical research services by adding GLP-compliant cell-based-therapies support capability

Company to launch new service at next week’s “ISSCR 2017 Annual Meeting” “CBSET is the ideal partner in preparing, presenting, and defending GLP studies for regulatory review.”—Michael Naimark, CBSET LEXINGTON, Mass., June 8, 2017  — CBSET Inc., a non-profit GLP translational research institute that specializes in the advancement of novel therapies, announced today that it has […]

CX 2017: Peripheral Innovation: Evaluation of a novel paclitaxel coated intravascular balloon

Peripheral Innovation: Evaluation of a novel paclitaxel coated intravascular balloon. Rami Tzafriri, PhD Summary: The presentation illustrated an innovative preclinical paradigm for evaluating and optimizing novel drug-coated balloon technologies by combining bioanalysis with imaging of the coating distribution. Presented at: CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.

EuroIntervention: Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents

Kolandaivelu K, Bailey L, Buzzi S, Zucker A, Milleret V, Ziogas A, Ehrbar M, Khattab AA, Stanley JRL, Wong GK, Zani B, Markham PM, Tzafriri AR, Bhatt DL, Edelman ER. Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. Summary: Simple surface modifications can enhance coronary […]

Society for Biomaterials: *BTI* From Benchtop to Clinical Trial: Examples of technology development

*BTI* From Benchtop to Clinical Trial: Examples of technology development. Rami Tzafriri, PhD Summary: Drawing on examples from renal denervation and other thought-leader debates at the conference, the presentation focused on several issues, including whether benchtop-to-clinical is the only path for new medical technologies, the roles and advantages of preclinical vs clinical trials in technology development, and […]

Interventional Cardiology Clinics: Mechanisms Underlying Drug Delivery to Peripheral Arteries.

Li J, Tzafriri R, Patel SM, Parikh SA. Mechanisms Underlying Drug Delivery to Peripheral Arteries. Summary: Delivery of drugs onto arterial targets via endovascular devices commands several principles: dissolution, diffusion, convection, drug binding, barriers to absorption, and interaction between the drug, delivery vehicle, and accepting arterial wall. The understanding of drug delivery in the coronary […]

Annals of Biomedical Engineering: Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling

Georgia S. Karanasiou, Michail I. Papafaklis, Claire Conway, Lampros K. Michalis, Rami Tzafriri, Elazer R. Edelman, Dimitrios I. Fotiadis. Stents: Biomechanics, Biomaterials, and Insights from Computational Modeling Summary: Coronary stents have revolutionized the treatment of coronary artery disease. Improvement in clinical outcomes requires detailed evaluation of the performance of stent biomechanics and the effectiveness as well […]

Press Release: Safety and Efficacy of New Class of Orthopedic Implant for Intramedullary Biologic Stabilization of Fractured Long Bones Studied Out to 1 Year

CBSET, IlluminOss Medical Data Published in Journal of Orthopaedic Research IlluminOss* System provides minimally invasive approach designed to replace splints, casts, metal fixator plates and rods to stabilize broken bones LEXINGTON, Mass., March 23, 2017 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, announced today it […]