“We are committed to investing in state-of-the-art technologies that advance the most effective preclinical science for our Sponsors” – Peter M. Markham, President and CEO, CBSET LEXINGTON, Mass., November 19, 2013 — CBSET, a not-for-profit preclinical research institute dedicated to biomedical research, education, and advancement of medical technologies, has expanded its preclinical development capabilities with the installation […]
Keating J, Markham M, Stanley J, Tzafriri AR, Wong G, Spognardi AM, Fuimaono K, Grunewald D, O’Fallon P, Edelman ER. ‘Electrode irrigation alters RF ablation treatment zone geometry and preserves medial and adventitial tissue while maintaining injury to renal nerves.’ Podium presentation at: Transcatheter Cardiovascular Therapeutics (TCT); 2013 Oct 28-Nov 1; Washington, DC. Summary: We quantitatively […]
“We will report a breakthrough: an experimental computational methodology for understanding and predicting lesion geometry following radiofrequency (RF) renal denervation treatment to lower hypertension. We expect that our research will have a significant effect on the development of devices that will be able to more precisely and selectively deliver RF or other types of energy […]
Tzafriri AR, Markham PM, LaRochelle AW, Cohen I, Richter Y, Edelman ER. ‘Computational Modeling Accurately Predicts In Vivo Arterial Elimination of Sirolimus-Analog Eluting Stents.’ Presented at: FDA – ASME Frontiers in Medical Devices meeting, University College, MD, 2013.
Tzafriri, AR, Artzi, N. Computational Modeling of Biomaterial Degradation and Local Drug Release Facilitates Rapid Device Development, Enhanced Performance & Regulatory Evaluation. Summary: Biodegradable materials are popular platforms for biocompatible and tunable local drug release. However, controlling and predicting material degradation dynamics, and the associated drug release kinetics in the complex in vivo environment often proves […]
David E. Haines, MD, FHRS; Charles Haffajee, MD, FHRS; Michael V. Orlov, MD, FACC; James R.L. Stanley, DVM, MS, DACVP; Rose Baird, MS; Julie Broderick, MSc; Claire Williams, MA; Ding He, MD, FHRS. ‘Microbubble and Emboli Production from Left Atrial Ablation with an RF Mesh Ablation System vs. Irrigated Tip Ablation: Outcomes of an Extracorporeal […]
Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy Summary:Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention […]
Keating JH, Wong G, Tzafriri AR, Zani BG, Baird R, Spognardi AM, Bailey L, LeBrun T, Stanley JRL, Markham PM. ‘Systematic Optimization of Targeted Renal Denervation Therapies Using the Porcine Model: Integration of quantitative biomarker analysis, computer modeling, and histopathologic techniques.’ Presented at: TRENDS, Frankfurt, Germany, 2013
P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. Journal of Histotechnology, 2013 March; 36 (1): 25-29.
Tzafriri AR, Edelman ER. ‘Understanding the Influence of Stent Design on Arterial Drug Distribution and Effect through Computational Modeling.’ Poster presented at: Annual Meeting of the Society for Biomaterials, Boston, MA, 2013.