Tzafriri AR. ‘Multi-scale modeling in local drug delivery: Implications for the evaluation of drug eluting stents and balloon technologies.’ Transcatheter Cardiovascular Therapeutics, Washington, DC, 2010.
Groothius A, Seifert P, Wong G, Spognardi AM, Markham P, Price S, Edelman ER, Rogers C. ‘A Comprehensive Analysis of DES and Bare Metal Stents Using Morphometric SEM Images of Overlapping Stent Pairs in a Rabbit Iliac Model to Assess Overall Healing.’ Transcatheter Cardiovascular Therapeutics, Washington, DC, 2010.
Baker A, Chatzizisis Y, Beigel R, Jonas M, Stone B, Coskun A, Maynard C, Rogers C, Koskinas K, Feldman C, Stone P, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic hyperlipidemic swine. Summary: Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about […]
Burke S; Blair A; Mendenhall HV; Stanley J; Groothuis A. ‘Topical Elastase Increases AVG Outflow Vein Diameter and Lumen Area in a Swine Model.’ Poster presented at: AngioAccess for Hemodialysis; 2010 June 14-16; Tours, France. Summary: PRT-201 is a recombinant human pancreatic elastase under development as a treatment to improve AVF maturation and prolong AVG patency. […]
Balcells M, Martorell J, Olive C, Santacana M, Chitalia V, Cardoso A, Edelman ER. Smooth muscle cells orchestrate the endothelial cell response to flow and injury. Summary: Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial cell (EC) toxicity. The […]
Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. . T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. Summary: Endothelial cells (EC) embedded within three-dimensional matrices (MEEC) when placed in the vascular adventitia control lumenal inflammation and intimal hyperplasia. Matrix-embedding alters endothelial immunogenicity in vitro. T helper (Th) driven […]
Tzafriri A, Vukmirovic N, Kolachalama V, Astafieve I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. Summary: Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy […]
Tzafriri AR, Groothuis A, Edelman ER. ‘Computational Model Predicts Multi-Phasic Drug Elution Kinetics From Bulk Degrading Inlays in Stent Reservoirs.’ FDA/NHLBI/NSF Workshop on Computer Methods for Cardiovascular Devices, Bethesda, MD, 2010.
Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. Summary: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely understood. It is still not evident how to efficiently determine the efficacy of […]
Groothius A, Seifert P, Spognardi AM, Stanley JRL, Markham P, Price S, Edelman ER, Rogers C. ‘Effect of Stent Design on Endothelialization in the Rabbit Iliac Model.’ Transcatheter Cardiovascular Therapeutics, San Francisco, CA, 2009.