Journal of Controlled Release: Lesion complexity determines arterial drug distribution after local drug delivery

Tzafriri A, Vukmirovic N, Kolachalama V, Astafieve I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery.

Summary: Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial drug distribution with tissue ultrastructure and composition in abdominal aortae from atherosclerotic human autopsy specimens and rabbits with lesions induced by dietary manipulation and controlled injury.

Journal of Controlled Release 2010 Mar;142(3): 332-338.

 

March 19, 2010