Rami Tzafriri; Peter Markham; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’
Presented at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel.
Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this however has never been validated and this we examined. Paclitaxel (PTX) coated balloons (W.L. Gore, Flagstaff AZ) with 4.1 (5×40 mm) or 3.6 μg/mm2 (6×40 mm) PTX were inflated for 60 sec once or three DCB sequentially at the same angiographic site in 30 Yorkshire swine peripheral arteries.
Tissue retention from DCB benefits from repeat inflations but not due to increased dose exposure – suggesting that repeated dilation may prepare the artery for enhanced absorption and/or overcome restrictions of single dose retention. These studies beg further evaluation in disease models and reevaluation of clinical use protocols for DCB.