Circ Res: Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals

M Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals.

Summary: Diabetes and insulin resistance are associated with increased disease risk and poor outcomes from cardiovascular interventions. Even drug-eluting stents exhibit reduced efficacy in patients with diabetes. We now report the first study of vascular response to stent injury in insulin-resistant and diabetic animal models.

Circ Res 2005 Sep 30;97(7):725-33. Epub 2005 Aug 25

September 30, 2005