FOCUS ON PERIPHERAL ARTERY DISEASE (PAD)

In Europe and North America, an estimated 27 million individuals are affected with peripheral artery disease (PAD), which is caused by the accumulation of plaque in peripheral arteries (commonly the pelvis or leg) reducing blood flow. Left untreated, PAD can lead to severe pain, immobility, non-healing wounds and eventually limb amputation. With risk factors such as diabetes and obesity on the rise, the prevalence of PAD is growing at double-digit rates.

CBSET is committed to the development of novel experimental and computational models for defining the barrier effects of tissue components on drugs of interest and evaluating novel endovascular therapies. CBSET’s scientists have published a range of data and analyses on PAD treatments and related therapies, including the most recent paper, Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosispublished in the Journal of Controlled Release, which provides critical insights into the barrier effects of calcified plaque on drug delivery and the treatment success of adjunctive lesion preparation therapy.

Recent scientific papers related to novel PAD therapies:

Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. Abraham R. Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R. Edelman,  Journal of Controlled Release, Volume 264, 28 October 2017, Pages 203-210.

Mechanisms Underlying Drug Delivery to Peripheral Arteries. Li J, Tzafriri R, Patel SM, Parikh SA. Interventional Cardiology Clinics. 2017 Apr;6(2):197-216. doi: 10.1016/j.iccl.2016.12.004.

Two Blades-Up Runs Using the JetStream Navitus Atherectomy Device Achieve Optimal Tissue Debulking of Nonocclusive In-Stent Restenosis: Observations From a Porcine Stent/Balloon Injury Model. Shammas NW, Aasen N, Bailey L, Budrewicz J, Farago T, Jarvis G. Journal of Endovascular Therapy. 2015 Aug;22(4):518-24.

Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy. Vijaya B. Kolachalama, Stephen D. Pacetti, Joseph W. Franses, John J. Stankus, Hugh Q. Zhao, Tarek Shazly, Alexander Nikanorov, Lewis B. Schwartz, Abraham R. Tzafriri, Elazer R. Edelman. Circulation. 2013;127:2047-2055.

Correlative evaluation of variable pressure-scanning electron microscopy to histology methods for vascular tissues. P. Seifert, K. Regan, B.G. Zani, G. Wong, and J. Stanley. Journal of Histotechnology, 2013 March; 36 (1): 25-29.

Related CBSET Brochures:

CBSET GLP Preclinical Services

Cardiovascular Research

GLP Histopathology and Morphometry

Computational Modeling of Local Drug Delivery

Scanning Electron Microscopy