World Pharma Today: Stem Cell and Regenerative Therapies for Hearing Loss

by Michael Naimark, Director of Business Development, CBSET, Inc. and Marie-Pierre Pasdelou, PharmD, founder and the Chief Development Officer, CILcare The year 2018 marks a notable milestone in the history of stem cells and regenerative medicine. In the last 20 years new technologies such as induced pluripotent stem cell lines (iPSCs) and CRISPR/Cas9 editing are […]

Cardiovascular Revascularization Medicine: Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency

Lauder L, Ewen S, Tzafriri AR, Edelman ER, Cremers B, Kulenthiran S, Ukena C, Linz D, Kindermann I, Tsioufis C, Scheller B, Böhm M, Mahfoud F. Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Summary: Because little is known of the impact of renal anatomy and procedural parameters […]

Journal of Controlled Release: Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings

Tzafriri AR, Garcia-Polite F, Li X, Keating J, Balaguer JM, Zani B, Bailey L, Markham P, Kiorpes TC, Carlyle W, Edelman ER. Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings. Summary: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial […]

PLoS One: Sex differences in the outcomes of stent implantation in mini-swine model

Kunio M, Wong G, Markham PM, Edelman ER. Sex differences in the outcomes of stent implantation in mini-swine model. Summary: Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related […]

EuroIntervention: Lost in translational filters between peers

Kolandaivelu K, Tzafriri AR. Lost in translational filters between peers. Summary: In a recent issue of EuroIntervention, two articles(1)(2) and an editorial(3) detailed the translational journey taken by Qvanteq’s ultra-hydrophilic stent platform. Bench-top studies and animal experiments in two species of swine as well as rabbits suggested that a reduction in restenosis and stent thrombosis might […]

The International Journal of Cardiology Imaging: Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images

Mie Kunio, Caroline C. O’Brien, Augusto C. Lopes Jr., Lynn Bailey, Pedro A. Lemos, Guillermo J. Tearney, Elazer R. Edelman. Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images. Summary: IThree-dimensional reconstruction of a vessel centerline from paired planar coronary angiographic images is critical to reconstruct the complex three-dimensional structure of the coronary artery […]

Respirology: Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter

Tsukada H, Entcheva-Dimitrov P, Ernst A, Rafeq S, Keating JH, Seward KP, Yarmus L. Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter. Summary: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity of treatment […]

World Pharma Today: Auditory Therapy, Ototoxicity, and GLP Compliance: Will the promising market for ear disorder treatments follow ophthalmology’s dramatic growth curve?

by Michael Naimark, Director of Business Development, CBSET, Inc. and Marie-Pierre Pasdelou, PharmD, founder and the Chief Development Officer, CILcare Hearing research and development aims to prevent hearing loss, halt its progression, or reverse deficits through a range of approaches. Unfortunately progress to date has been limited and the FDA has yet to recognize any […]