Abraham Rami Tzafriri, Lynn Bailey, John Keating, Peter Markham, Debashis Dutta, Margaret Kayo, Elazer R. Edelman. ‘Sirolimus analog lipophilicity dictates release kinetics and tissue retention after implantation of polymer free drug coated stents.’ Poster presented at: EuroPCR, May 16-19, 2017, Paris, France.
Peripheral Innovation: Evaluation of a novel paclitaxel coated intravascular balloon. Rami Tzafriri, PhD Summary: The presentation illustrated an innovative preclinical paradigm for evaluating and optimizing novel drug-coated balloon technologies by combining bioanalysis with imaging of the coating distribution. Presented at: CX 2017 – The Charing Cross International Symposium, April 25-28, Kensington, London, UK.
*BTI* From Benchtop to Clinical Trial: Examples of technology development. Rami Tzafriri, PhD Summary: Drawing on examples from renal denervation and other thought-leader debates at the conference, the presentation focused on several issues, including whether benchtop-to-clinical is the only path for new medical technologies, the roles and advantages of preclinical vs clinical trials in technology development, and […]
John Keating, Brett Zani, James RL Stanley, Peter Markham. ‘Assessment of a Novel Rabbit Atheroma Model Utilizing Combined Dietary Modification, Balloon Injury and Administration of Pro-Calcific Agents.’ Poster presented at: American College of Veterinary Pathologists (ACVP), Dec 3-7, 2016, New Orleans, LA.
Rami Tzafriri. ‘New and Revisited Targets for Autonomic Modulation: the Pathophysiology Behind.’ Invited Presentation at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel.
Rami Tzafriri; Peter Markham; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Presented at: Innovations in Cardiovascular Interventions (ICI), Dec 4-6, 2016, Tel Aviv, Israel. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this […]
Rami Tzafriri; Brett Zani; Steve Alston; Elazer Edelman. ‘Multiple drug coated balloon exposures increase arterial permeability and drug retention.’ Poster presented at: Transcatheter Cardiovascular Therapeutics (TCT), Oct 25-Nov 2, 2016, Washington, DC. Summary: It is thought that increased dose or number of drug-coated balloon (DCB) inflations increases drug delivery and tissue retention – this however has […]
L Bailey, AS; M Gilvarry; M Holian; R Tzafriri, PhD, J Keating, DVM, DACVP, E Edelman, MD, PhD, FACC. ‘Preclinical Evaluation of Mechanical Thrombectomy Devices in a Swine Clot Model.’ Summary: Successful recanalization (TICI ≥2b) using mechanical thrombectomy (MT) with stent retriever devices is associated with good outcomes in the treatment of ischemic stroke. Preclinical TICI […]
Tzafriri A, Garcia-polite F, Schulz-jander D, Melder R, Goshgarian J, Tunev S, Stone G, Edelman E. ‘Solubility-controlled sirolimus release from drug-filled stents.’ Summary: Whereas drug diffusion is typically the rate-limiting release mechanism observed in other polymer-coated drug-eluting stents (DES), drug release from prototype DFS is determined by a complex dissolution-precipitation mechanism sensitive to the equilibrium solubility […]
Tzafriri A., Nikanorov A., Zani B., Stanley J., Garcia-polite F., Budrewicz J., Knutson J., Kohler R., Markham P., Edelman E. ‘Plaque modification with an orbital atherectomy system enhances drug distribution in calcified peripheral arteries.’ Summary: Calcific atherosclerosis is a major challenge to intraluminal drug delivery treatments in peripheral artery disease. We evaluated the effects of […]