EuroPCR: Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier

Kumaran Kolandaivelu, Josep Maria Balaguer, Maria Tomas Gracia, Jose Manuel Sanes, Enric Estruch, Laura Perkins, Syed Hossainy, Rami Tzafriri, Peter Markham, Elazer Edelman. “Local, regional, and systemic factors in BRS thrombosis in small vessels: understanding the sub-2.5mm barrier.“ Summary: Device thrombosis dominates bioresorbable vascular scaffolds (BVS) safety concerns, particularly in sub-2.5mm vessels. To better understand […]

EuroPCR: Visualizing and quantifying differential distribution of balloon-delivered coating to porcine arteries

Abraham R. Tzafriri; Arben Muraj; Fernando Garcia-Polite; Peter Markham; Brett Zani; Anna-Maria Spognardi; Steve Alston; Elazer R. Edelman. “Visualizing and quantifying differential distribution of balloon-delivered coating to porcine arteries.“ Summary: Drug coated balloons are a promising therapy for peripheral artery disease, but efficacy varies between devices and with lesion complexity. The accepted hypothesis that coating […]

EuroPCR: Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents

Tzafriri AR, Rotllant Daurella L,Keating JH, Garcia Polite F, Li X, Bailey L, Markham PM, Dutta D, Stoll HP, Edelman ER. “Visualizing the tissue distribution and retention of Sirolimus and analog delivered from polymer free drug coated stents” Summary: Biolimus A9 is a highly lipophilic Sirolimus analog (13-fold the lipophilicity of the parent drug) specifically […]

Tufts CTSI Translational Day 2017: Lessons learned from the front lines

Rami Tzafriri, PhD and Michael Naimark, MS. “Lessons Learned from the Front Lines.” Summary: The Directors of Research and Innovation and Business Development presented advice and lessons learned from CBSET Inc.’s experiences on how to differentiate a new technology and navigate through a successful path to the market, and how to find the correct testing paradigm […]

TCT 2017: Stent based tissue drug and binding target protein distributions: durable versus deployable coatings

Rami Tzafriri, PhD. “Stent based tissue drug and binding target protein distributions: durable versus deployable coatings.” Summary: We developed immunofluorescence (IF) methods to track drug and target protein distribution in stented arteries, to aid the development and assessment of novel stent designs. Xience Pro (74 μg Everolimus/3.0×15 mm, durable coating) and MiStent (135 μg Sirolimus/3.0×15 mm, […]

ASR and AALAS: Benecalorie Nutritional Supplement as a Component of Liquid Diet in Swine

Misty Williams-Fritze DVM, MS, DACLAM. “Academy of Surgical Research: Benecalorie Nutritional Supplement as a Component of Liquid Diet in Swine.” Summary: Swine are commonly utilized in research of the gastrointestinal tract (GIT), where unobstructed access to the upper or lower GIT is necessary for biomedical device evaluation. We regularly use a liquid diet developed by our facility, […]

Academy of Surgical Research: Novel, Minimally Invasive, Toxin Administration into the Pericardial Space for the Developlment of Heart Failure in Swine

Jay Budrewicz, Kenta Nakamura, Mikhail Maslov, Anna Spognardi, Misty Williams-Fritze, Brett Zani, John Keating, Peter Markham, Mark Lovich, Elazer Edelman. “Novel, Minimally Invasive, Toxin Administration into the Pericardial Space for the Developlment of Heart Failure in Swine.” Summary: Due to the growing population of adult cancer survivors, there is a dramatically increasing patient population developing heart […]

SIB 2017: Particulate embolization from catheter coatings

Rami Tzafriri, PhD. ‘Particulate embolization from catheter coatings.’ Summary: Medical catheters permit minimally invasive external access for monitoring, imaging, sampling, local delivery of therapeutic agents, and placement of devices like endovascular stents, aneurysm coils and transcatheter valves. Catheter coatings are employed extensively as enhancers of device lubriciousness/ steerability and as platforms for local drug delivery. […]

VIVA2017: Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention

Rami Tzafriri, PhD. “Plaxitel-Coated PTA Balloon Catheter: microcrystalline coating for improved delivery and retention.” Summary: Drug coated balloons are a promising therapy for peripheral arterial disease, but differences in efficacy between devices and non-responders cannot be understood using current methods. To address this void, we developed methods for visualizing and quantifying coating distribution on arterial surfaces […]