ATVB|PVD Scientific Sessions: Intravascular Molecular-Structural Imaging of Arterial Permeability In Vivo to Optimize Paclitaxel Drug-Coated Balloon Treatment of Restenosis

Mazen S Albaghdadi MD MS, Zhonglie Piao PhD, Adam Mauskapf B2, Mohammed Chowdhury MBChB MRCS, Rami Tzafriri PhD, Elazer Edelman MD PhD, Guillermo Tearney MD PhD, Farouc Jaffer MD PhD. “Intravascular Molecular-Structural Imaging of Arterial Permeability In Vivo to Optimize Paclitaxel Drug-Coated Balloon Treatment of Restenosis.”

Summary: The efficacy of paclitaxel (PTX) drug-coated balloons (DCBs) in reducing restenosis is limited by Inadequate arterial permeability (AP), yet in vivo approaches for imaging AP in atherosclerosis are limited. We applied intravascular near-infrared fluorescence-optical coherence tomography (NIRF-OCT) molecular imaging of indocyanine green (ICG), a validated approach to assess AP in vivo. We sought to characterize the ability of NIRF-OCT/ICG to detect changes in AP following plaque modification, the impact of DCB on AP over time, and the ability of ICG to serve as a biomarker of PTX uptake.

Poster presented at ATVB|PVD Scientific Sessions, May 14–16, 2019, Boston, MA.